Article
Association of p53 codon 72 genotypes and clinical outcome in human papillomavirus-infected lung cancer patients.
The Annals of thoracic surgery - 1 Apr 2013
Chen Shih-Pin, Hsu Nan-Yung, Wu Jeng-Yuan, Chen Chih-Yi, Chou Ming-Chih, Lee Huei, Cheng Ya-Wen
Abstract excerpt
BACKGROUND: We recently reported that high-risk human papillomavirus (HPV) 16/18 E6 protein was associated with p53 protein degradation in lung cancer. The present study addressed the relationship between the different p53 genotypes and HPV oncoprotein expression with respect to p53 protein degradation and clinical outcome in primary lung cancer patients. METHODS: We examined whether p53 codon 72 polymorphism and...
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