Article
Associations of TP53 mutations, codon 72 polymorphism and human papillomavirus in head and neck squamous cell carcinoma patients.
Oncology reports - 1 Dec 2013
Shi Qi, Xiao Kang, Wei Wei, Zhang Bao-Yun, Chen Cao, Xu Yin, Chen Li-Na, Song Yun-Tao, Ma Xiao, Zhang Nai-Song, Dong Xiao-Ping
Abstract excerpt
To investigate the possible associations between mutations in TP53 and phenotypes of single-nucleotide polymorphisms (SNPs) in codon 72 (SNP72) with the expression profiles of p53 and human papillomavirus (HPV) infection, 93 pathologically diagnosed head and neck squamous cell carcinomas (HNSCCs) were included for study. Using PCR and direct sequencing, 45 TP53 mutations in 35 cases (37.6%) were confirmed out of...
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