Article
Human Papillomavirus 16 Physical Status and the TP53 Codon 72 Polymorphism in Japanese HPV-Positive Oropharyngeal Cancer Patients.
ORL; journal for oto-rhino-laryngology and its related specialties - 1 Jan 2016
Saito Yuki, Ando Mizuo, Fujimoto Chisato, Omura Go, Kobayashi Kenya, Asakage Takahiro, Yamasoba Tatsuya
Abstract excerpt
BACKGROUND: In human papillomavirus (HPV)-induced carcinogenesis, the arginine (Arg) allele of the TP53 codon 72 polymorphism binds more efficiently to the HPV E6 oncoprotein than the proline (Pro) allele. We investigated the physical status of HPV-16 DNA and the TP53 codon 72 polymorphism in oropharyngeal squamous cell carcinoma (OPSCC). METHODS: Tumor samples from 70 p16-positive OPSCC patients were tested for...
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