Article
Potential increase in the prognostic value of p53 mutation by Pro72 allele in stage I non-small-cell lung cancer.
Annals of surgical oncology - 1 Jul 2009
Chien Wen-Pin, Wong Ruey-Hong, Wu Tsu-Chin, Cheng Ya-Wen, Chen Chih-Yi, Lee Huei
Abstract excerpt
BACKGROUND: Accumulated evidence suggests that p53 function altered by its gene mutation or genetic polymorphism contributes to tumor malignancy. Association of p53 mutation and its codon 72 polymorphism with lung cancer prognosis has been extensively studied. However, the joint effect of p53 mutation and p53 codon 72 polymorphism on lung cancer prognosis remains uncertain. METHODS: In the present study, 266...
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