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Article

p53 codon 72 polymorphism associated with risk of human papillomavirus-associated squamous cell carcinoma of the oropharynx in never-smokers.

Carcinogenesis - 1 Apr 2008

Ji Xuemei, Neumann Ana S, Sturgis Erich M, Adler-Storthz Karen, Dahlstrom Kristina R, Schiller John T, Wei Qingyi, Li Guojun

Abstract excerpt

The tumor suppressor p53 protein can be bound, degraded and inactivated by the human papillomavirus (HPV) E6 oncoprotein. The p53 protein's susceptibility to this oncoprotein may be influenced by the p53 codon 72 polymorphism, but the role of such a polymorphism in the development of HPV16-associated squamous cell carcinoma of the oropharynx (SCCOP) has not been established. To investigate the role of the p53...

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PMID: 18258602
DOI: 10.1093/carcin/bgn039

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