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Article

Spontaneous insertion of a b2 element in the ptpn6 gene drives a systemic autoinflammatory disease in mice resembling neutrophilic dermatosis in humans.

The American journal of pathology - 1 Apr 2011

Nesterovitch Andrew B, Szanto Sandor, Gonda Andrea, Bardos Tamas, Kis-Toth Katalin, Adarichev Vyacheslav A, Olasz Katalin, Ghassemi-Najad Sheida, Hoffman Mark D, Tharp Michael D, Mikecz Katalin, Glant Tibor T

Abstract excerpt

We found a spontaneous autosomal mutation in a mouse leading to neutrophil infiltration with ulceration in the upper dermis of homozygous offspring. These animals had increased neutrophil numbers, associated with normal lymphocyte count, in peripheral blood and bone marrow, suggesting a myeloproliferative disorder; however, granulocyte precursor proliferation in bone marrow was actually reduced (because...

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Identifiers

PMID: 21435452
DOI: 10.1016/j.ajpath.2010.12.053
PMCID: PMC3078426

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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