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Article

B and T cells are not required for the viable motheaten phenotype.

The Journal of experimental medicine - 1 Feb 1996

Yu C C, Tsui H W, Ngan B Y, Shulman M J, Wu G E, Tsui F W

Abstract excerpt

Hematopoietic cell phosphatase (HCP), encoded by the hcph gene, (also called PTP1C, SHP, SH-PTP1, and PTPN6) is deficient in motheaten (me/me), and the allelic viable motheaten (me(v)/me(v)) mice. Since HCP is expressed in many cell types and protein phosphorylation is a major mechanism of regulating protein function, it is not surprising that the motheaten phenotype is pleiotropic. It is commonly thought that...

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Identifiers

PMID: 8627150
DOI: 10.1084/jem.183.2.371
PMCID: PMC2192436

Genes

PTPN6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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B and T cells are not required for the viable motheaten phenotype.PMID 8627150Read ↗

Motheaten and viable motheaten mice have mutations in the haematopoietic cell phosphatase gene.Semantic proximity Read ↗

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Molecular basis of the motheaten phenotype.Semantic proximity Read ↗

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Investigations into the regulation and function of the SH2 domain-containing protein-tyrosine phosphatase, SHP-1.Semantic proximity Read ↗

Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene.Semantic proximity Read ↗

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