Motheaten, an immunodeficient mutant of the mouse. I. Genetics and pathology.

doi:10.1093/oxfordjournals.jhered.a108625

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Article

Motheaten, an immunodeficient mutant of the mouse. I. Genetics and pathology.

The Journal of heredity - 1 Jan 2000

Green M C, Shultz L D

Abstract excerpt

A new recessive mutation, motheaten (me), is on chromosome 6, 21.9 +/- 4.3 recombination units distal to white (Miwh). Mice homozygous for the new mutation have neutrophilic lesions of the skin beginning as early as day 1, and pneumonitis with many macrophages in the alveoli as early as day 3. Th...

Topics

Animals
Antibodies
Blood Cell Count
Bone Marrow
Chromosome Mapping
Female
Genes, Recessive
Genetic Linkage
Immunologic Deficiency Syndromes
Kidney
Lung
Lymphoid Tissue
Male
Mice
Mice, Inbred C57BL
Mutation
Organ Size
Skin

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