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Article

Tyrosine Kinase SYK Licenses MyD88 Adaptor Protein to Instigate IL-1α-Mediated Inflammatory Disease.

Immunity - 18 Apr 2017

Gurung Prajwal, Fan Gaofeng, Lukens John R, Vogel Peter, Tonks Nicholas K, Kanneganti Thirumala-Devi

Abstract excerpt

Mice carrying a hypomorphic point mutation in the Ptpn6 gene (Ptpn6spin mice) develop an inflammatory skin disease that resembles neutrophilic dermatosis in humans. Here, we demonstrated that interleukin-1α (IL-1α) signaling through IL-1R and MyD88 in both stromal and immune cells drive inflammation in Ptpn6spin mice. We further identified SYK as a critical kinase that phosphorylates MyD88, promoted...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Myeloid Differentiation Factor 88

Share to Protein Tyrosine Phosphatase, Non-Receptor Type 6

Share to Receptor-Interacting Protein Serine-Threonine Kinases

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Source

Open in PubMed Open full text

Identifiers

PMID: 28410990
DOI: 10.1016/j.immuni.2017.03.014
PMCID: PMC5501252

Genes

SYK
RIPK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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