Article
Quantitative trait analysis of yeast biodiversity yields novel gene tools for metabolic engineering.
Metabolic engineering - 1 May 2013
Hubmann Georg, Foulquié-Moreno Maria R, Nevoigt Elke, Duitama Jorge, Meurens Nicolas, Pais Thiago M, Mathé Lotte, Saerens Sofie, Nguyen Huyen Thi Thanh, Swinnen Steve, Verstrepen Kevin J, Concilio Luigi, de Troostembergh Jean-Claude, Thevelein Johan M
Abstract excerpt
Engineering of metabolic pathways by genetic modification has been restricted largely to enzyme-encoding structural genes. The product yield of such pathways is a quantitative genetic trait. Out of 52 Saccharomyces cerevisiae strains phenotyped in small-scale fermentations, we identified strain CBS6412 as having unusually low glycerol production and higher ethanol yield as compared to an industrial reference...
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