Article
Whole genome sequencing of Saccharomyces cerevisiae: from genotype to phenotype for improved metabolic engineering applications.
BMC genomics - 22 Dec 2010
Otero José Manuel, Vongsangnak Wanwipa, Asadollahi Mohammad A, Olivares-Hernandes Roberto, Maury Jérôme, Farinelli Laurent, Barlocher Loïc, Osterås Magne, Schalk Michel, Clark Anthony, Nielsen Jens
Abstract excerpt
BACKGROUND: The need for rapid and efficient microbial cell factory design and construction are possible through the enabling technology, metabolic engineering, which is now being facilitated by systems biology approaches. Metabolic engineering is often complimented by directed evolution, where selective pressure is applied to a partially genetically engineered strain to confer a desirable phenotype. The exact...
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