Article
Integrative phenomics reveals insight into the structure of phenotypic diversity in budding yeast.
Genome research - 1 Sept 2013
Skelly Daniel A, Merrihew Gennifer E, Riffle Michael, Connelly Caitlin F, Kerr Emily O, Johansson Marnie, Jaschob Daniel, Graczyk Beth, Shulman Nicholas J, Wakefield Jon, Cooper Sara J, Fields Stanley, Noble William S, Muller Eric G D, Davis Trisha N, Dunham Maitreya J, Maccoss Michael J, Akey Joshua M
Abstract excerpt
To better understand the quantitative characteristics and structure of phenotypic diversity, we measured over 14,000 transcript, protein, metabolite, and morphological traits in 22 genetically diverse strains of Saccharomyces cerevisiae. More than 50% of all measured traits varied significantly across strains [false discovery rate (FDR) = 5%]. The structure of phenotypic correlations is complex, with 85% of all...
Topics
- Genetic Variation
- Genome, Fungal
- Phenotype
- Quantitative Trait Loci
- Saccharomyces cerevisiae
- Transcriptome