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Article

Quantitative Trait Loci (QTL)-Guided Metabolic Engineering of a Complex Trait.

ACS synthetic biology - 17 Mar 2017

Maurer Matthew J, Sutardja Lawrence, Pinel Dominic, Bauer Stefan, Muehlbauer Amanda L, Ames Tyler D, Skerker Jeffrey M, Arkin Adam P

Abstract excerpt

Engineering complex phenotypes for industrial and synthetic biology applications is difficult and often confounds rational design. Bioethanol production from lignocellulosic feedstocks is a complex trait that requires multiple host systems to utilize, detoxify, and metabolize a mixture of sugars and inhibitors present in plant hydrolysates. Here, we demonstrate an integrated approach to discovering and optimizing...

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PMID: 27936603
DOI: 10.1021/acssynbio.6b00264

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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