Article
Confirming genes influencing risk to cleft lip with/without cleft palate in a case-parent trio study.
Human genetics - 1 Jul 2013
Beaty T H, Taub M A, Scott A F, Murray J C, Marazita M L, Schwender H, Parker M M, Hetmanski J B, Balakrishnan P, Mansilla M A, Mangold E, Ludwig K U, Noethen M M, Rubini M, Elcioglu N, Ruczinski I
Abstract excerpt
A collection of 1,108 case-parent trios ascertained through an isolated, nonsyndromic cleft lip with or without cleft palate (CL/P) was used to replicate the findings from a genome-wide association study (GWAS) conducted by Beaty et al. (Nat Genet 42:525-529, 2010), where four different genes/regions were identified as influencing risk to CL/P. Tagging SNPs for 33 different genes were genotyped (1,269 SNPs). All...
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