Article
A genome-wide association study of cleft lip with and without cleft palate identifies risk variants near MAFB and ABCA4.
Nature genetics - 1 Jun 2010
Beaty Terri H, Murray Jeffrey C, Marazita Mary L, Munger Ronald G, Ruczinski Ingo, Hetmanski Jacqueline B, Liang Kung Yee, Wu Tao, Murray Tanda, Fallin M Daniele, Redett Richard A, Raymond Gerald, Schwender Holger, Jin Sheng-Chih, Cooper Margaret E, Dunnwald Martine, Mansilla Maria A, Leslie Elizabeth, Bullard Stephen, Lidral Andrew C, Moreno Lina M, Menezes Renato, Vieira Alexandre R, Petrin Aline, Wilcox Allen J, Lie Rolv T, Jabs Ethylin W, Wu-Chou Yah Huei, Chen Philip K, Wang Hong, Ye Xiaoqian, Huang Shangzhi, Yeow Vincent, Chong Samuel S, Jee Sun Ha, Shi Bing, Christensen Kaare, Melbye Mads, Doheny Kimberly F, Pugh Elizabeth W, Ling Hua, Castilla Eduardo E, Czeizel Andrew E, Ma Lian, Field L Leigh, Brody Lawrence, Pangilinan Faith, Mills James L, Molloy Anne M, Kirke Peadar N, Scott John M, Scott James M, Arcos-Burgos Mauricio, Scott Alan F
Abstract excerpt
Case-parent trios were used in a genome-wide association study of cleft lip with and without cleft palate. SNPs near two genes not previously associated with cleft lip with and without cleft palate (MAFB, most significant SNP rs13041247, with odds ratio (OR) per minor allele = 0.704, 95% CI 0.635-0.778, P = 1.44 x 10(-11); and ABCA4, most significant SNP rs560426, with OR = 1.432, 95% CI 1.292-1.587, P = 5.01 x...
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