Article
Maternal transmission effects of the PAX genes among cleft case-parent trios from four populations.
European journal of human genetics : EJHG - 1 Jun 2009
Sull Jae Woong, Liang Kung-Yee, Hetmanski Jacqueline B, Fallin Margaret Daniele, Ingersoll Roxanne G, Park Jiwan, Wu-Chou Yah-Huei, Chen Philip K, Chong Samuel S, Cheah Felicia, Yeow Vincent, Park Beyoung Yun, Jee Sun Ha, Jabs Ethylin W, Redett Richard, Scott Alan F, Beaty Terri H
Abstract excerpt
Isolated cleft lip with or without cleft palate (CL/P) is among the most common human birth defects, with a prevalence of 1 in 700 live births. The paired box (PAX) genes have been suggested as candidate genes for CL/P based largely on mouse models; however, few human studies have focused on this gene family. This study tests for association between markers in four PAX genes and CL/P using a case-parent trio...
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