Article
A multi-ethnic genome-wide association study identifies novel loci for non-syndromic cleft lip with or without cleft palate on 2p24.2, 17q23 and 19q13.
Human molecular genetics - 1 Jul 2016
Leslie Elizabeth J, Carlson Jenna C, Shaffer John R, Feingold Eleanor, Wehby George, Laurie Cecelia A, Jain Deepti, Laurie Cathy C, Doheny Kimberly F, McHenry Toby, Resick Judith, Sanchez Carla, Jacobs Jennifer, Emanuele Beth, Vieira Alexandre R, Neiswanger Katherine, Lidral Andrew C, Valencia-Ramirez Luz Consuelo, Lopez-Palacio Ana Maria, Valencia Dora Rivera, Arcos-Burgos Mauricio, Czeizel Andrew E, Field L Leigh, Padilla Carmencita D, Cutiongco-de la Paz Eva Maria C, Deleyiannis Frederic, Christensen Kaare, Munger Ronald G, Lie Rolv T, Wilcox Allen, Romitti Paul A, Castilla Eduardo E, Mereb Juan C, Poletta Fernando A, Orioli Iêda M, Carvalho Flavia M, Hecht Jacqueline T, Blanton Susan H, Buxó Carmen J, Butali Azeez, Mossey Peter A, Adeyemo Wasiu L, James Olutayo, Braimah Ramat O, Aregbesola Babatunde S, Eshete Mekonen A, Abate Fikre, Koruyucu Mine, Seymen Figen, Ma Lian, de Salamanca Javier Enríquez, Weinberg Seth M, Moreno Lina, Murray Jeffrey C, Marazita Mary L
Abstract excerpt
Orofacial clefts (OFCs), which include non-syndromic cleft lip with or without cleft palate (CL/P), are among the most common birth defects in humans, affecting approximately 1 in 700 newborns. CL/P is phenotypically heterogeneous and has a complex etiology caused by genetic and environmental factors. Previous genome-wide association studies (GWASs) have identified at least 15 risk loci for CL/P. As these loci do...
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