Article
Genome-wide association study of multiethnic nonsyndromic orofacial cleft families identifies novel loci specific to family and phenotypic subtypes.
Genetic epidemiology - 1 Apr 2022
Mukhopadhyay Nandita, Feingold Eleanor, Moreno-Uribe Lina, Wehby George, Valencia-Ramirez Luz Consuelo, Restrepo Muñeton Claudia P, Padilla Carmencita, Deleyiannis Frederic, Christensen Kaare, Poletta Fernando A, Orioli Ieda M, Hecht Jacqueline T, Buxó Carmen J, Butali Azeez, Adeyemo Wasiu L, Vieira Alexandre R, Shaffer John R, Murray Jeffrey C, Weinberg Seth M, Leslie Elizabeth J, Marazita Mary L
Abstract excerpt
Nonsyndromic orofacial clefts (OFCs) are among the most common craniofacial birth defects worldwide, and known to exhibit phenotypic and genetic heterogeneity. Cleft lip plus cleft palate (CLP) and cleft lip only (CL) are commonly combined together as one phenotype (CL/P), separately from cleft palate alone. In comparison, our study analyzes CL and CLP separately. A sample of 2218 CL and CLP cases, 4537...
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