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Article

HSF4 regulates DLAD expression and promotes lens de-nucleation.

Biochimica et biophysica acta - 1 Aug 2013

Cui Xiukun, Wang Lei, Zhang Jing, Du Rong, Liao Shengjie, Li Duanzhuo, Li Chang, Ke Tie, Li David Wan-Cheng, Huang Hua, Yin Zhan, Tang Zhaohui, Liu Mugen

Abstract excerpt

HSF4 mutations lead to both congenital and age-related cataract. The purpose of this study was to explore the mechanism of cataract formation caused by HSF4 mutations. The degradation of nuclear DNA is essential for the lens fiber differentiation. DNase 2β (DLAD) is highly expressed in lens cells, and mice with deficiencies in the DLAD gene develop nuclear cataracts. In this study, we found that HSF4 promoted the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23507146
DOI: 10.1016/j.bbadis.2013.03.007

Genes

HSF4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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