Article
Pax6 is essential for lens fiber cell differentiation.
Development (Cambridge, England) - 1 Aug 2009
Shaham Ohad, Smith April N, Robinson Michael L, Taketo Makoto M, Lang Richard A, Ashery-Padan Ruth
Abstract excerpt
The developing ocular lens provides an excellent model system with which to study the intrinsic and extrinsic cues governing cell differentiation. Although the transcription factors Pax6 and Sox2 have been shown to be essential for lens induction, their later roles during lens fiber differentiation remain largely unknown. Using Cre/loxP mutagenesis, we somatically inactivated Pax6 and Sox2 in the developing mouse...
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