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Article

GammaD-crystallin associated protein aggregation and lens fiber cell denucleation.

Investigative ophthalmology & visual science - 1 Aug 2007

Wang Kaijun, Cheng Catherine, Li Lin, Liu Haiquan, Huang Qingling, Xia Chun-Hong, Yao Ke, Sun Peiqing, Horwitz Joseph, Gong Xiaohua

Abstract excerpt

PURPOSE: To understand the underlying molecular mechanism for a dominant cataract caused by a point mutation in the gammaD-crystallin gene. METHODS: A dominant cataractous mouse line was identified from chemically induced mouse mutations by phenotypic screening with slit lamp examination. Genomewide linkage analysis and DNA sequencing were used to determine the causative gene mutation. Histology,...

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PMID: 17652744
DOI: 10.1167/iovs.06-1487

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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