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Article

Mutation of Dock5, a member of the guanine exchange factor Dock180 superfamily, in the rupture of lens cataract mouse.

Experimental eye research - 1 May 2008

Omi Natsue, Kiyokawa Etsuko, Matsuda Michiyuki, Kinoshita Kazuo, Yamada Shuichi, Yamada Kazumi, Matsushima Yoshibumi, Wang Yun, Kawai Jun, Suzuki Masanori, Hayashizaki Yoshihide, Hiai Hiroshi

Abstract excerpt

Rupture of lens cataract (RLC) in the mouse is a spontaneous mutation inherited by a single autosomal recessive gene mapped on chromosome 14. Fine mapping of the mutant locus revealed a nucleotide deletion of 27-bp at the end of 15th exon of Dock5 (Dedicator of cytokinesis-5), a member of the Doc...

Read the complete abstract on PubMed

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Share to Cataract
Share to DNA, Complementary

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Eye Proteins

Share to Genes, Recessive

Share to Guanine Nucleotide Exchange Factors

Share to Lens, Crystalline

Share to Mice, Inbred BALB C

Share to Rupture, Spontaneous

Source

Identifiers

PMID: 18396277
DOI: 10.1016/j.exer.2008.02.011

Genes

DOCK5
RAC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-18396277-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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