Article
Functional analysis of the Hsf4(lop11) allele responsible for cataracts in lop11 mice.
Molecular vision - 1 Jan 2011
Liang Lina, Liegel Ryan, Endres Brad, Ronchetti Adam, Chang Bo, Sidjanin D J
Abstract excerpt
PURPOSE: Lens opacity 11 (lop11) is a spontaneous autosomal recessive mouse mutation resulting in cataracts. Insertion of an early transposable element (ETn) in intron 9 of heat shock factor 4 (Hsf4) was previously identified as responsible for lop11 cataracts. Although molecular analysis showed that the ETn insertion resulted in an aberrant Hsf4 transcript encoding a truncated mutant HSF4(lop11) protein, the...
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