Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Removal of Hsf4 leads to cataract development in mice through down-regulation of gamma S-crystallin and Bfsp expression.

BMC molecular biology - 19 Feb 2009

Shi Xiaohe, Cui Bin, Wang Zhugang, Weng Lin, Xu Zhongping, Ma Jinjin, Xu Guotong, Kong Xiangyin, Hu Landian

Abstract excerpt

BACKGROUND: Heat-shock transcription factor 4 (HSF4) mutations are associated with autosomal dominant lamellar cataract and Marner cataract. Disruptions of the Hsf4 gene cause lens defects in mice, indicating a requirement for HSF4 in fiber cell differentiation during lens development. However, neither the relationship between HSF4 and crystallins nor the detailed mechanism of maintenance of lens transparency by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cataract
Share to Down-Regulation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Eye Proteins

Share to gamma-Crystallins

Share to Heat Shock Transcription Factors

Share to Intermediate Filament Proteins

Share to Lens, Crystalline

Share to Protein Processing, Post-Translational

Source

Open in PubMed Open full text

Identifiers

PMID: 19224648
DOI: 10.1186/1471-2199-10-10
PMCID: PMC2653017

Genes

HSF4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Removal of Hsf4 leads to cataract development in mice through down-regulation of gamma S-crystallin and Bfsp expression.PMID 19224648Read ↗

Unique contribution of heat shock transcription factor 4 in ocular lens development and fiber cell differentiation.Semantic proximity Read ↗

Functional analysis of HSF4 mutations found in patients with autosomal recessive congenital cataracts.Semantic proximity Read ↗

Functional analysis of the Hsf4(lop11) allele responsible for cataracts in lop11 mice.Semantic proximity Read ↗

The inhibition of CMV promoter by heat shock factor 4b is regulated by Daxx.Semantic proximity Read ↗

Proteomic analysis of SRA01/04 transfected with wild-type and mutant HSF4b identified from a Chinese congenital cataract family.Semantic proximity Read ↗

Expression of the HSF4 DNA binding domain-EGFP hybrid gene recreates early childhood lamellar cataract in transgenic mice.Semantic proximity Read ↗

Mutation screening of HSF4 in 150 age-related cataract patients.Semantic proximity Read ↗

Alterations to proteins in the lens of hereditary Crygs-mutated cataractous mice.Semantic proximity Read ↗

HSF4 regulates DLAD expression and promotes lens de-nucleation.Semantic proximity Read ↗

Loss of αBa-crystallin, but not αA-crystallin, increases age-related cataract in the zebrafish lensSemantic proximity Read ↗

Probing the changes in gene expression due to α-crystallin mutations in mouse models of hereditary human cataract.Semantic proximity Read ↗

Heat shock transcription factors and sensory placode development.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.