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Article

Removal of Hsf4 leads to cataract development in mice through down-regulation of gamma S-crystallin and Bfsp expression.

BMC molecular biology - 19 Feb 2009

Shi Xiaohe, Cui Bin, Wang Zhugang, Weng Lin, Xu Zhongping, Ma Jinjin, Xu Guotong, Kong Xiangyin, Hu Landian

Abstract excerpt

BACKGROUND: Heat-shock transcription factor 4 (HSF4) mutations are associated with autosomal dominant lamellar cataract and Marner cataract. Disruptions of the Hsf4 gene cause lens defects in mice, indicating a requirement for HSF4 in fiber cell differentiation during lens development. However, n...

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Source

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Identifiers

PMID: 19224648
DOI: 10.1186/1471-2199-10-10
PMCID: PMC2653017

Genes

HSF4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-19224648-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Removal of Hsf4 leads to cataract development in mice through down-regulation of gamma S-crystallin and Bfsp expression.PMID 19224648Read ↗

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