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Fibronectin matrix assembly is essential for cell condensation during chondrogenesis

1 Jan 2014

Abstract excerpt

Mesenchymal cell condensation is the initiating event in endochondral bone formation. Cell condensation is followed by differentiation into chondrocytes, which is accompanied by induction of chondrogenic gene expression. Gene mutations involved in chondrogenesis cause chondrodysplasias and other skeletal defects. Using mesenchymal stem cells (MSCs) in an in vitro chondrogenesis assay, we found that knockdown of...

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PMID: 25146392
DOI: 10.1242/jcs.150276

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