Article
Leptin signaling in Kiss1 neurons arises after pubertal development.
PloS one - 1 Jan 2013
Cravo Roberta M, Frazao Renata, Perello Mario, Osborne-Lawrence Sherri, Williams Kevin W, Zigman Jeffery M, Vianna Claudia, Elias Carol F
Abstract excerpt
The adipocyte-derived hormone leptin is required for normal pubertal maturation in mice and humans and, therefore, leptin has been recognized as a crucial metabolic cue linking energy stores and the onset of puberty. Several lines of evidence have suggested that leptin acts via kisspeptin expressing neurons of the arcuate nucleus to exert its effects. Using conditional knockout mice, we have previously...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.