Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Specific subpopulations of hypothalamic leptin receptor-expressing neurons mediate the effects of early developmental leptin receptor deletion on energy balance

6 Jun 2018

Abstract excerpt

OBJECTIVE: To date, early developmental ablation of leptin receptor (LepRb) expression from circumscribed populations of hypothalamic neurons (e.g., arcuate nucleus (ARC) Pomc- or Agrp-expressing cells) has only minimally affected energy balance. In contrast, removal of LepRb from at least two large populations (expressing vGat or Nos1) spanning multiple hypothalamic regions produced profound obesity and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipokines, Inflammation, and Metabolic Diseases
Share to Hypothalamic control of reproductive hormones
Share to Regulation of Appetite and Obesity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29914853
DOI: 10.1016/j.molmet.2018.06.001

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Specific subpopulations of hypothalamic leptin receptor-expressing neurons mediate the effects of early developmental leptin receptor deletion on energy balancePMID 29914853Read ↗

Leptin signaling in Kiss1 neurons arises after pubertal development.Semantic proximity Read ↗

Specific Physiological Roles for Signal Transducer and Activator of Transcription 3 in Leptin Receptor-Expressing NeuronsSemantic proximity Read ↗

Conditional knockout of leptin receptor in neural stem cells leads to obesity in mice and affects neuronal differentiation in the hypothalamus early after birth.Semantic proximity Read ↗

Transcriptomic Profiling of Developing Melanocortin Neurons Reveals a Role for Prdm12 in Energy BalanceSemantic proximity Read ↗

Hypothalamic neural projections are permanently disrupted in diet-induced obese rats.Semantic proximity Read ↗

Development of Leptin‐Sensitive CircuitsSemantic proximity Read ↗

Expression of a hypomorphic Pomc allele alters leptin dynamics during late pregnancy.Semantic proximity Read ↗

Post-embryonic ablation of AgRP neurons in mice leads to a lean, hypophagic phenotype.Semantic proximity Read ↗

Selective deletion of leptin receptor in neurons leads to obesity.Semantic proximity Read ↗

Comparative Transcriptomic Analyses of Developing Melanocortin Neurons Reveal New Regulators for the Anorexigenic Neuron IdentitySemantic proximity Read ↗

The thermogenic effect of leptin is dependent on a distinct population of prolactin-releasing peptide neurons in the dorsomedial hypothalamus.Semantic proximity Read ↗

Transcriptional and physiological roles for STAT proteins in leptin actionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.