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Article

POMC neurons control fertility through differential signaling of MC4R in Kisspeptin neurons

2024-02-21

Abstract excerpt

Inactivating mutations in the melanocortin 4 receptor ( MC4R ) gene cause monogenic obesity. Interestingly, female patients also display various degrees of reproductive disorders, in line with the subfertile phenotype of MC4RKO female mice. However, the cellular mechanisms by which MC4R regulates reproduction are unknown. Kiss1 neurons directly stimulate gonadotropin-releasing hormone (GnRH) release through two d...

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Literature Corpus work
2e02d67b-ab3d-5679-b54b-af3a25050f24
DOI
10.1101/2024.02.18.580873
Open publication

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POMC neurons control fertility through differential signaling of MC4R in Kisspeptin neuronsDOI 10.1101/2024.02.18.580873
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