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Article

Kisspeptin and KISS1R: a critical pathway in the reproductive system.

Reproduction (Cambridge, England) - 1 Sept 2008

Gianetti Elena, Seminara Stephanie

Abstract excerpt

In 2003, three groups around the world simultaneously discovered that KISS1R (GPR54) is a key gatekeeper of sexual maturation in both mice and men. Developmental changes in the expression of the ligand for KISS1R, kisspeptin, support its critical role in the pubertal transition. In addition, kisspeptin, a powerful stimulus of GNRH-induced gonadotropin secretion and may modulate both positive and negative sex...

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Share to Gonadotropin-Releasing Hormone
Share to Hypogonadism
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Luteinizing Hormone

Share to Puberty, Precocious

Share to Receptors, G-Protein-Coupled

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Source

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Identifiers

PMID: 18515314
DOI: 10.1530/REP-08-0091
PMCID: PMC2858313

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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