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Article

Redundancy in Kiss1 expression safeguards reproduction in the mouse.

Endocrinology - 1 Aug 2013

Popa Simina M, Moriyama Ryutaro M, Caligioni Claudia S, Yang Jasmine J, Cho Caroline M, Concepcion Tessa L, Oakley Amy E, Lee In Hae, Sanz Elisenda, Amieux Paul S, Caraty Alain, Palmiter Richard D, Navarro Victor M, Chan Yee-Ming, Seminara Stephanie B, Clifton Donald K, Steiner Robert A

Abstract excerpt

Kisspeptin (Kiss1) signaling to GnRH neurons is widely acknowledged to be a prerequisite for puberty and reproduction. Animals lacking functional genes for either kisspeptin or its receptor exhibit low gonadotropin secretion and infertility. Paradoxically, a recent study reported that genetic ablation of nearly all Kiss1-expressing neurons (Kiss1 neurons) does not impair reproduction, arguing that neither Kiss1...

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Identifiers

PMID: 23736293
DOI: 10.1210/en.2013-1222
PMCID: PMC3713212

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