Article
New genetic factors implicated in human GnRH-dependent precocious puberty: the role of kisspeptin system.
Molecular and cellular endocrinology - 22 Oct 2011
Teles Milena Gurgel, Silveira Leticia Ferreira Gontijo, Tusset Cintia, Latronico Ana Claudia
Abstract excerpt
Human puberty is triggered by the reemergence of GnRH pulsatile secretion with progressive activation of the gonadal function. A number of genes have been identified in the complex regulatory neuroendocrine network that controls puberty initiation. KISS1 and KISS1R genes, which encode kisspeptin and its cognate receptor, respectively, are considered crucial factors for acquisition of normal reproductive function....
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