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Article

Role of kisspeptin/GPR54 system in human reproductive axis.

Frontiers of hormone research - 1 Jan 2010

Silveira Leticia F G, Teles Milena G, Trarbach Ericka B, Latronico Ana Claudia

Abstract excerpt

The kisspeptin-GPR54 signaling complex is a key gatekeeper of human sexual maturation. Kisspeptins, encoded by the KISS1 gene, constitute a powerful stimulus for gonadotropin-releasing hormone-induced gonadotropin secretion. In addition, the KISS1 gene is a target for regulation by gonadal steroids in both sexes. The increase in hypothalamic kisspeptin expression at puberty is believed to contribute to maturation...

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Source

Identifiers

PMID: 20389082
DOI: 10.1159/000312689

Genes

KISS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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