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Article

Bivariate segmentation of SNP-array data for allele-specific copy number analysis in tumour samples.

BMC bioinformatics - 5 Mar 2013

Mosén-Ansorena David, Aransay Ana María

Abstract excerpt

BACKGROUND: SNP arrays output two signals that reflect the total genomic copy number (LRR) and the allelic ratio (BAF), which in combination allow the characterisation of allele-specific copy numbers (ASCNs). While methods based on hidden Markov models (HMMs) have been extended from array comparative genomic hybridisation (aCGH) to jointly handle the two signals, only one method based on change-point detection,...

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Identifiers

PMID: 23497144
DOI: 10.1186/1471-2105-14-84
PMCID: PMC3599505

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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