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Article

PICNIC: an algorithm to predict absolute allelic copy number variation with microarray cancer data.

Biostatistics (Oxford, England) - 1 Jan 2010

Greenman Chris D, Bignell Graham, Butler Adam, Edkins Sarah, Hinton Jon, Beare Dave, Swamy Sajani, Santarius Thomas, Chen Lina, Widaa Sara, Futreal P Andy, Stratton Michael R

Abstract excerpt

High-throughput oligonucleotide microarrays are commonly employed to investigate genetic disease, including cancer. The algorithms employed to extract genotypes and copy number variation function optimally for diploid genomes usually associated with inherited disease. However, cancer genomes are aneuploid in nature leading to systematic errors when using these techniques. We introduce a preprocessing...

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Identifiers

PMID: 19837654
DOI: 10.1093/biostatistics/kxp045
PMCID: PMC2800165

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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