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Article

WaveCNV: allele-specific copy number alterations in primary tumors and xenograft models from next-generation sequencing.

Bioinformatics (Oxford, England) - 15 Mar 2014

Holt Carson, Losic Bojan, Pai Deepa, Zhao Zhen, Trinh Quang, Syam Sujata, Arshadi Niloofar, Jang Gun Ho, Ali Johar, Beck Tim, McPherson John, Muthuswamy Lakshmi B

Abstract excerpt

MOTIVATION: Copy number variations (CNVs) are a major source of genomic variability and are especially significant in cancer. Until recently microarray technologies have been used to characterize CNVs in genomes. However, advances in next-generation sequencing technology offer significant opportunities to deduce copy number directly from genome sequencing data. Unfortunately cancer genomes differ from normal...

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PMID: 24192544
DOI: 10.1093/bioinformatics/btt611
PMCID: PMC3957071

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