Article
CNAnova: a new approach for finding recurrent copy number abnormalities in cancer SNP microarray data.
Bioinformatics (Oxford, England) - 1 Jun 2010
Ivakhno Sergii, Tavaré Simon
Abstract excerpt
MOTIVATION: The current generation of single nucleotide polymorphism (SNP) arrays allows measurement of copy number aberrations (CNAs) in cancer at more than one million locations in the genome in hundreds of tumour samples. Most research has focused on single-sample CNA discovery, the so-called segmentation problem. The availability of high-density, large sample-size SNP array datasets makes the identification...
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