Article
Allele-specific multi-sample copy number segmentation in ASCAT.
Bioinformatics (Oxford, England) - 27 Jul 2021
Ross Edith M, Haase Kerstin, Van Loo Peter, Markowetz Florian
Abstract excerpt
MOTIVATION: Allele-specific copy number alterations are commonly used to trace the evolution of tumours. A key step of the analysis is to segment genomic data into regions of constant copy number. For precise phylogenetic inference, breakpoints shared between samples need to be aligned to each other. RESULTS: Here, we present asmultipcf, an algorithm for allele-specific segmentation of multiple samples that...
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