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Article

Reconstructing DNA copy number by joint segmentation of multiple sequences.

BMC bioinformatics - 16 Aug 2012

Zhang Zhongyang, Lange Kenneth, Sabatti Chiara

Abstract excerpt

BACKGROUND: Variations in DNA copy number carry information on the modalities of genome evolution and mis-regulation of DNA replication in cancer cells. Their study can help localize tumor suppressor genes, distinguish different populations of cancerous cells, and identify genomic variations responsible for disease phenotypes. A number of different high throughput technologies can be used to identify copy number...

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Identifiers

PMID: 22897923
DOI: 10.1186/1471-2105-13-205
PMCID: PMC3534631

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