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Article

Systematic evaluation of validated type 2 diabetes and glycaemic trait loci for association with insulin clearance.

Diabetologia - 1 Jun 2013

Goodarzi M O, Guo X, Cui J, Jones M R, Haritunians T, Xiang A H, Chen Y-D I, Taylor K D, Buchanan T A, Hsueh W A, Raffel L J, Rotter J I

Abstract excerpt

AIMS/HYPOTHESIS: Insulin clearance is a highly heritable trait, for which few quantitative trait loci have been discovered. We sought to determine whether validated type 2 diabetes and/or glycaemic trait loci are associated with insulin clearance. METHODS: Hyperinsulinaemic-euglycaemic clamps were performed in two Hispanic-American family cohorts totalling 1329 participants in 329 families. The Metabochip was...

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Source

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Identifiers

PMID: 23494448
DOI: 10.1007/s00125-013-2880-6
PMCID: PMC3651757

Genes

AGMO
CDKAL1
DGKB
FADS1
GLIS3
IGF1
JAZF1
LYPLAL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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