Article
Whole genome sequence association analysis of fasting glucose and fasting insulin levels in diverse cohorts from the NHLBI TOPMed program.
Communications biology - 28 Jul 2022
DiCorpo Daniel, Gaynor Sheila M, Russell Emily M, Westerman Kenneth E, Raffield Laura M, Majarian Timothy D, Wu Peitao, Sarnowski Chloé, Highland Heather M, Jackson Anne, Hasbani Natalie R, de Vries Paul S, Brody Jennifer A, Hidalgo Bertha, Guo Xiuqing, Perry James A, O'Connell Jeffrey R, Lent Samantha, Montasser May E, Cade Brian E, Jain Deepti, Wang Heming, D'Oliveira Albanus Ricardo, Varshney Arushi, Yanek Lisa R, Lange Leslie, Palmer Nicholette D, Almeida Marcio, Peralta Juan M, Aslibekyan Stella, Baldridge Abigail S, Bertoni Alain G, Bielak Lawrence F, Chen Chung-Shiuan, Chen Yii-Der Ida, Choi Won Jung, Goodarzi Mark O, Floyd James S, Irvin Marguerite R, Kalyani Rita R, Kelly Tanika N, Lee Seonwook, Liu Ching-Ti, Loesch Douglas, Manson JoAnn E, Minster Ryan L, Naseri Take, Pankow James S, Rasmussen-Torvik Laura J, Reiner Alexander P, Reupena Muagututi'a Sefuiva, Selvin Elizabeth, Smith Jennifer A, Weeks Daniel E, Xu Huichun, Yao Jie, Zhao Wei, Parker Stephen, Alonso Alvaro, Arnett Donna K, Blangero John, Boerwinkle Eric, Correa Adolfo, Cupples L Adrienne, Curran Joanne E, Duggirala Ravindranath, He Jiang, Heckbert Susan R, Kardia Sharon L R, Kim Ryan W, Kooperberg Charles, Liu Simin, Mathias Rasika A, McGarvey Stephen T, Mitchell Braxton D, Morrison Alanna C, Peyser Patricia A, Psaty Bruce M, Redline Susan, Shuldiner Alan R, Taylor Kent D, Vasan Ramachandran S, Viaud-Martinez Karine A, Florez Jose C, Wilson James G, Sladek Robert, Rich Stephen S, Rotter Jerome I, Lin Xihong, Dupuis Josée, Meigs James B, Wessel Jennifer, Manning Alisa K
Abstract excerpt
The genetic determinants of fasting glucose (FG) and fasting insulin (FI) have been studied mostly through genome arrays, resulting in over 100 associated variants. We extended this work with high-coverage whole genome sequencing analyses from fifteen cohorts in NHLBI's Trans-Omics for Precision Medicine (TOPMed) program. Over 23,000 non-diabetic individuals from five race-ethnicities/populations (African, Asian,...
