Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic associations vary across the spectrum of fasting serum insulin: results from the European IDEFICS/I.Family children's cohort.

Diabetologia - 1 Oct 2023

Mehlig Kirsten, Foraita Ronja, Nagrani Rajini, Wright Marvin N, De Henauw Stefaan, Molnár Dénes, Moreno Luis A, Russo Paola, Tornaritis Michael, Veidebaum Toomas, Lissner Lauren, Kaprio Jaakko, Pigeot Iris

Abstract excerpt

AIMS/HYPOTHESIS: There is increasing evidence for the existence of shared genetic predictors of metabolic traits and neurodegenerative disease. We previously observed a U-shaped association between fasting insulin in middle-aged women and dementia up to 34 years later. In the present study, we performed genome-wide association (GWA) analyses for fasting serum insulin in European children with a focus on variants...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dementia
Share to Fasting

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome-Wide Association Study

Share to Insulin

Share to Neurodegenerative Diseases

Share to Polymorphism, Single Nucleotide

Share to Ubiquitin-Protein Ligases

Source

Open in PubMed Open full text

Identifiers

PMID: 37420130
DOI: 10.1007/s00125-023-05957-w
PMCID: PMC10473990

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic associations vary across the spectrum of fasting serum insulin: results from the European IDEFICS/I.Family children's cohort.PMID 37420130Read ↗

Systematic evaluation of validated type 2 diabetes and glycaemic trait loci for association with insulin clearance.Semantic proximity Read ↗

Association of genetic Loci with glucose levels in childhood and adolescence: a meta-analysis of over 6,000 children.Semantic proximity Read ↗

Relationship between glucose homeostasis and obesity in early life-a study of Italian children and adolescents.Semantic proximity Read ↗

Early Life Adversity and Polygenic Risk for High Fasting Insulin Are Associated With Childhood ImpulsivitySemantic proximity Read ↗

Genetic Susceptibility Determines β-Cell Function and Fasting Glycemia Trajectories Throughout Childhood: A 12-Year Cohort Study (EarlyBird 76).Semantic proximity Read ↗

Genome-wide scans for heritability of fasting serum insulin and glucose concentrations in hypertensive families.Semantic proximity Read ↗

Association of the IGF1 gene with fasting insulin levels.Semantic proximity Read ↗

Associations of Genetic Susceptibility to Alzheimer's Disease with Adiposity and Cardiometabolic Risk Factors among Children in a 2-Year Follow-up Study.Semantic proximity Read ↗

Insulin resistance: Genetic associations with depression and cognition in population based cohortsSemantic proximity Read ↗

Genomewide meta‐analysis identifies loci associated with <scp>IGF</scp> ‐I and <scp>IGFBP</scp> ‐3 levels with impact on age‐related traitsSemantic proximity Read ↗

The influence of rare genetic variation in SLC30A8 on diabetes incidence and β-cell function.Semantic proximity Read ↗

A quantitative trait locus on chromosome 13q affects fasting glucose levels in Hispanic children.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.