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Article

Insulin clearance: confirmation as a highly heritable trait, and genome-wide linkage analysis.

Diabetologia - 1 Aug 2012

Guo X, Cui J, Jones M R, Haritunians T, Xiang A H, Chen Y-D I, Taylor K D, Buchanan T A, Davis R C, Hsueh W A, Raffel L J, Rotter J I, Goodarzi M O

Abstract excerpt

AIMS/HYPOTHESIS: We have previously documented a high heritability of insulin clearance in a Hispanic cohort. Here, our goal was to confirm the high heritability in a second cohort and search for genetic loci contributing to insulin clearance. METHODS: Hyperinsulinaemic-euglycaemic clamps were performed in 513 participants from 140 Hispanic families. Heritability was estimated for clamp-derived insulin clearance...

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Identifiers

PMID: 22584727
DOI: 10.1007/s00125-012-2577-2
PMCID: PMC3391346

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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