Article

Type 2 diabetes genetics in 125,000 admixed adults from Mexico City

2026-06-25

Abstract excerpt

<h4>Summary</h4> Type 2 diabetes (T2D) is a highly heritable, polygenic disease with over 600 loci identified through genome-wide association studies (GWAS). However, despite possessing unique genetic variation shaped by demographic history and admixture, Latin American populations remain markedly underrepresented in global genomic research. To address this gap, we conducted genome- and exome-wide analyses of 19,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a99577cc-d60b-5f9b-809b-83245e69eaa9
DOI: 10.64898/2026.06.23.26356360

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Type 2 diabetes genetics in 125,000 admixed adults from Mexico CityDOI 10.64898/2026.06.23.26356360Read

Population-Scale, Genotype-First Characterization of Monogenic Diabetes in 374,973 Multi-Ancestry Individuals from the <i>All of Us</i> Research ProgramSemantic proximity Read

An ancestry-enriched HNF4A variant and GP2 reveal distinct mechanisms of type 2 diabetes in exome-wide study of 13,674 cases and 41,024 controlsSemantic proximity Read

Rare variant association analysis in 51,256 type 2 diabetes cases and 370,487 controls informs the spectrum of pathogenicity of monogenic diabetes genesSemantic proximity Read

Rare variant analyses in 51,256 type 2 diabetes cases and 370,487 controls reveal the pathogenicity spectrum of monogenic diabetes genes.Semantic proximity Read

Genetic Epidemiology of Type 2 Diabetes in Mexican MestizosSemantic proximity Read

Genome-wide association study of type 2 diabetes in a sample from Mexico City and a meta-analysis of a Mexican-American sample from Starr County, Texas.Semantic proximity Read

Maturity Onset Diabetes of the Young (MODY) is not always monogenic: candidate genes involved in a Latino PopulationSemantic proximity Read

Genetic architecture and biology of youth-onset type 2 diabetesSemantic proximity Read

Genomic landscape of Mexican patients with maturity onset diabetes of the young: beyond mutations in MODY-known genes.Semantic proximity Read

Association of common genetic variants with diabetes and metabolic syndrome related traits in the Arizona Insulin Resistance registry: a focus on Mexican American families in the Southwest.Semantic proximity Read

Insights from rare variants into the genetic architecture and biology of youth-onset type 2 diabetesSemantic proximity Read

Whole genome sequence association analysis of fasting glucose and fasting insulin levels in diverse cohorts from the NHLBI TOPMed program.Semantic proximity Read