Article

Mechanisms of Innate Immune Injury in Arrhythmogenic Cardiomyopathy

2023-07-13

Abstract excerpt

<h4>ABSTRACT</h4> Inhibition of nuclear factor kappa-B (NFκB) signaling prevents disease in Dsg2 mut/mut mice, a model of arrhythmogenic cardiomyopathy (ACM). Moreover, NFκB is activated in ACM patient-derived iPSC-cardiac myocytes under basal conditions in vitro . Here, we used genetic approaches and sequencing studies to define the relative pathogenic roles of immune signaling in cardiac myocytes vs. inflamm...

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Literature Corpus work: ad1d7908-db13-587b-ae93-325c908d941a
DOI: 10.1101/2023.07.12.548682

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