Article
The development of myocardial fibrosis in transgenic mice with targeted overexpression of tumor necrosis factor requires mast cell-fibroblast interactions.
Circulation - 8 Nov 2011
Zhang Weili, Chancey Amanda L, Tzeng Huei-Ping, Zhou Zhenqing, Lavine Kory J, Gao Feng, Sivasubramanian Natarajan, Barger Philip M, Mann Douglas L
Abstract excerpt
BACKGROUND: Transgenic mice with cardiac-restricted overexpression of tumor necrosis factor (MHCsTNF mice) develop progressive myocardial fibrosis, diastolic dysfunction, and adverse cardiac remodeling. Insofar as tumor necrosis factor (TNF) does not directly stimulate fibroblast collagen synthesis, we asked whether TNF-induced fibrosis was mediated indirectly through interactions between mast cells and cardiac...
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