Article

p38β/MAPK11 Deficiency Exacerbates Cardiac Structural and Electrophysiological Remodeling and Contributes to Immune Dysregulation in the Aging Heart

2026-06-23

Abstract excerpt

<h4>ABSTRACT</h4> Aging is a major risk factor for cardiac diseases, including heart failure, myocardial infarction, and arrhythmias. Activation of p38 MAPKs regulates cardiac remodeling and contributes to age-related cardiac dysfunction. However, the isoform-specific roles of p38 kinases in the aging heart remain poorly understood. Although p38β has been reported to exert cardioprotective effects in models of do...

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Literature Corpus work: a8fffa36-74fd-589f-a974-5615f40a40c5
DOI: 10.64898/2026.06.18.733182

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