Article
Interaction between maternal 5,10-methylenetetrahydrofolate reductase C677T and methionine synthase A2756G gene variants to increase the risk of fetal neural tube defects in a Shanxi Han population.
Chinese medical journal - 1 Mar 2013
Liu Zhi-zhen, Zhang Jun-tao, Liu Dan, Hao Yu-hui, Chang Bing-mei, Xie Jun, Li Pei-zhen
Abstract excerpt
BACKGROUND: The 5,10-methylenetetrahydrofolate reductase (MTHFR) and methionine synthase (MS) are attractive candidates for screening for risk of neural tube defects (NTDs). The aim of the current study was to investigate maternal MTHFR and MS polymorphisms and the interaction between them and th...
Topics
- 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
- China
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Genotype
- Humans
- Methylenetetrahydrofolate Reductase (NADPH2)
- Neural Tube Defects
- Polymorphism, Genetic