Article
Variants in maternal COMT and MTHFR genes and risk of neural tube defects in offspring.
Metabolic brain disease - 1 Apr 2015
Liu Jufen, Zhang Yali, Jin Lei, Li Guoxing, Wang Linlin, Bao Yanping, Fu Yunting, Li Zhiwen, Zhang Le, Ye Rongwei, Ren Aiguo
Abstract excerpt
Methylenetetrahydrofolate reductase (MTHFR) C677T and catechol-O-Methyltransferase (COMT) G158A are associated with a risk of neural tube defects (NTDs) in offspring. This study examined the effect of a MTHFR × COMT interaction on the risk of NTDs in a Chinese population with a high prevalence of NTDs. A total of 576 fetuses or newborns with NTDs and 594 controls were genotyped for MTHFRrs1801133, MTHFRrs1801131,...
Topics
- Adult
- Anencephaly
- Asian People
- Catechol O-Methyltransferase
- China
- Female
- Gene Frequency
- Genotype
- Humans
- Infant, Newborn
- Methylenetetrahydrofolate Reductase (NADPH2)
- Neural Tube Defects
- Parity
- Polymorphism, Single Nucleotide