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Article

HLA-DQ beta sequence polymorphism and genetic susceptibility to IDDM.

Diabetes - 1 Jan 1990

Erlich H A, Bugawan T L, Scharf S, Nepom G T, Tait B, Griffith R L

Abstract excerpt

The analysis of HLA-DQ beta nucleotide sequence polymorphism in insulin-dependent diabetes mellitus (IDDM) patients and control subjects suggests a role for the DQ beta-chain in genetic susceptibility. Sequence determination and oligonucleotide hybridization was carried out on enzymatically amplified DNA from various HLA-DR-typed individuals, including the rare class of DR2+ patients. In the analysis of DQ beta...

Topics

Alleles
Amino Acid Sequence
Base Sequence
Chromosome Mapping
DNA
Diabetes Mellitus, Type 1
Electrophoresis, Polyacrylamide Gel
Genetic Predisposition to Disease
HLA-DQ Antigens
HLA-DQ beta-Chains
HLA-DR4 Antigen

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Haplotypes

Humans

Molecular Sequence Data

Polymorphism, Genetic

Precipitin Tests

Source

Identifiers

PMID: 2210066
DOI: 10.2337/diacare.39.1.96

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2210066-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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