HLA-DQB1 alleles and absence of Asp 57 as susceptibility factors of IDDM in Finland.

doi:10.2337/diab.40.12.1640

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

HLA-DQB1 alleles and absence of Asp 57 as susceptibility factors of IDDM in Finland.

Diabetes - 1 Dec 1991

Reijonen H, Ilonen J, Knip M, Akerblom H K

Abstract excerpt

It has been proposed that negatively charged aspartic acid at position 57 of the HLA-DQ beta-chain determines resistance to development of insulin-dependent diabetes mellitus (IDDM), whereas genetic susceptibility to IDDM correlates with a neutral amino acid residue. The disease rate is very low in Oriental populations with high frequencies of Asp 57. This raises a question whether the high incidence of IDDM in...

Topics

Adolescent
Alleles
Amino Acid Sequence
Aspartic Acid
Base Sequence
Diabetes Mellitus, Type 1
Disease Susceptibility
Finland
Genetic Predisposition to Disease
Genotype
HLA-DQ Antigens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

HLA-DQ beta-Chains

Humans

Molecular Sequence Data

Oligodeoxyribonucleotides

Polymerase Chain Reaction

Reference Values

Source

Open in PubMed

Identifiers

PMID: 1756904
DOI: 10.2337/diab.40.12.1640

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1756904-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HLA-DQB1 alleles and absence of Asp 57 as susceptibility factors of IDDM in Finland.PMID 1756904Read ↗

Worldwide differences in the incidence of type I diabetes are associated with amino acid variation at position 57 of the HLA-DQ beta chain.Semantic proximity Read ↗

HLA-DQ beta sequence polymorphism and genetic susceptibility to IDDM.Semantic proximity Read ↗

Genetic susceptibility to type I diabetes: a review.Semantic proximity Read ↗

Analysis of HLA-DQ genotypes and susceptibility in insulin-dependent diabetes mellitus.Semantic proximity Read ↗

HLA-DQB 1 codon 57 and genetic susceptibility to type 1 (insulin-dependent) diabetes mellitus in French children.Semantic proximity Read ↗

Prevalence of HLA-DQ beta chain non-Asp alleles in type I (insulin-dependent) diabetics with young and older ages of onset.Semantic proximity Read ↗

Contribution of the absence of aspartic acid at position 57 of the HLA-DQ beta chain to predisposition to insulin-dependent diabetes mellitus in a southern Chinese population.Semantic proximity Read ↗

HLA-DQA and DQB alleles contribute to susceptibility to insulin-dependent diabetes mellitus.Semantic proximity Read ↗

HLA-DQA1 and DQB1 alleles in French and Algerian type 1 diabetic subjects.Semantic proximity Read ↗

The complex interplay of the DQB1 and DQA1 loci in the generation of the susceptible and protective phenotype for insulin-dependent diabetes mellitus.Semantic proximity Read ↗

Changes in frequency of IDDM-associated HLA DQB, CTLA4 and INS alleles.Semantic proximity Read ↗

The HLA-DQ beta non-Asp-57 allele: a predictor of future insulin-dependent diabetes mellitus in patients with autoimmune Addison's disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.